Publications

Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states

Muir J, Lin S, Aarrestad IK, Daniels HR, Ma J, Tian L, Olson DE, Kim CK (2024)

Science

Stochastic neuropeptide signals compete to calibrate the rate of satiation

Zhang SX, Kim A, Madara JC, Zhu PK, Christenson LF, Lutas A, Kalugin PN, Sunkavalli PS, Jin Y, Pal A, Tian L, Lowell BB, Andermann ML (2024)

Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations

Kim MJ, Gibson DJ, Hu D, Yoshida T, Hueske E, Matsushima A, Mahar A, Schofield CJ, Sompolpong P, Tran KT, Tian L, Graybiel AM (2024)

Nature Communications

Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

Wilmot JH, Diniz CRAF, Crestani AP, Puhger KR, Roshgadol J, Tian L, Wiltgen BJ (2024)

eLife

Unlocking opioid neuropeptide dynamics with genetically encoded biosensors

Dong C, Gowrishankar R, Jin Y, He XJ, Gupta A, Wang H, Sayar-Atasoy N, Flores RJ, Mahe K, Tjahjono N, Liang R, Marley A, Or Mizuno G, Lo DK, Sun Q, Whistler JL, Li B, Gomes I, Von Zastrow M, Tejeda HA, Atasoy D, Devi LA, Bruchas MR, Banghart MR, Tian L (2024)

Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research

Wright EC, Scott E, Tian L (2024)

Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states

Wang H, Flores RJ, Yarur HE, Limoges A, Bravo-Rivera H, Casello SM, Loomba N, Enriquez-Traba J, Arenivar M, Wang Q, Ganley R, Ramakrishnan C, Fenno LE, Kim Y, Deisseroth K, Or G, Dong C, Hoon MA, Tian L, Tejeda HA (2024)

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior

Vu MT, Brown EH, Wen MJ, Noggle CA, Zhang Z, Monk KJ, Bouabid S, Mroz L, Graham BM, Zhuo Y, Li Y, Otchy TM, Tian L, Davison IG, Boas DA, Howe MW (2024)

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Sayar-Atasoy N, Yavuz Y, Laule C, Dong C, Kim H, Rysted J, Flippo K, Davis D, Aklan I, Yilmaz B, Tian L, Atasoy D (2024)

Proceedings of the National Academy of Sciences

Sexual differentiation of neural mechanisms of stress sensitivity during puberty

Wright et al. (2023)

5-HT_FAsTR: A versatile, label-free, microplate assay to quantify serotonin transport and release using the genetically encoded fluorescent biosensor iSeroSnFR

Bukowski L, Strom M, Andersen J, Maesen J, Tian L, Sinning S (2023)

Research Square

Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Chuapcoco MR, Flytzani NC, Goeden N, Octeau JC, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos, LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich JK, Bishaw Y, Gore BB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V (2023)

Nature Nanotechnology

Competition between stochastic neuropeptide signals calibrates the rate of satiation

Zhang SX, Kim A, Madara JC, Zhu PK, Christenson LF, Lutas A, Kalugin PN, Jin Y, Pal A, Tian L, Lowell BB, Andermann ML (2023)

bioRxiv

Lighting up action potentials with fast and bright voltage sensors

Andreoni A, Tian L (2023)

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors

Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE (2023)

Science

Proceedings of the National Academy of Sciences

Behavioral encoding across timescales by region-specific dopamine dynamics

Jørgensen SH, Ejdrup AL, Lycas MD, Posselt LP, Madsen KL, Tian L, Dreyer JK, Herborg F, Sørensen AT, Gether U (2023)

Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor

Salinas AG, Lee JO, Augustin SM, Zhang S, Patriarchi T, Tian L, Morales M, Mateo Y, Lovinger DM (2023)

Nature Communications

Annual Review of Neuroscience

Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors

Dong C, Zheng Y, Long-Iyer K, Wright EC, Li Y, Tian L (2022)

Fluorescence screens for identifying central nervous system-acting drug-biosensor pairs for subcellular and supracellular pharmacokinetics

Beatty ZG, Muthusamy AK, Unger EK, Dougherty DA, Tian L, Looger LL, Shivange AV, Bera K, Lester HA, Nichols AL (2022)

Bio-Protocol

Phasic locus coeruleus activity facilitates hippocampus-dependent trace fear memory formation

Wilmot JH, Puhger K, Roshgadol J, Tian L, Wiltgen BJ (2022)

bioRxiv

Letting the little light of mind shine: Advances and future directions in neurochemical detection

Tjahjono N, Jin Y, Hsu A, Roukes M, Tian L (2022)

Neuroscience Research

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

Klein Herenbrink C, Støier JF, Reith WD, Dagra A, Gregorek MAC, Cola RB, Patriarchi T, Li Y, Tian L, Gether U, Herborg F (2022)

Communications Biology

The residence of synaptically released dopamine on D2 autoreceptors

Condon AF, Robinson BG, Asad N, Dore TM, Tian L, Williams JT (2021)

Cell-type specific asynchronous modulation of PKA by dopamine during reward-based learning

Lee SJ, Lodder B, Chen Y, Patriarchi T, Tian L, Sabatini B (2021)

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J (2021)

Nature Chemical Biology

Dopamine release in the nucleus accumbens core signals perceived saliency

Kutlu MG, Zachry JE, Melugin PR, Cajigas SA, Chevee MF, Kelly SJ, Kutlu B, Tian L, Siciliano CA, Calipari ES (2021)

Current Biology

Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition

Abraham AD, Casello SM, Schattauer SS, Wong BA, Mizuno GO, Mahe K, Tian L, Land BB, Chavkin C (2021)

NPP

A photoswitchable GPCR-based opsin for presynaptic inhibition

Copits BA, Gowrishankar R, O’Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L, Gautam N, Sunahara RK, Gereau RW, Bruchas MR (2021)

Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories

Melzer S, Newmark ER, Mizuno GO, Hyun M, Philson AC, Quiroli E, Righetti B, Gregory MR, Huang KW, Levasseur J, Tian L, Sabatini BL (2021)

Cell

Psychedelic-inspired drug discovery using an engineered biosensor

Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L (2021)

Cell

Integrated neurophotonics: Toward dense volumetric interrogation of brain circuit activity-at depth and in real time

Moreaux LC, Yatsenko D, Sacher WD, Choi J, Lee C, Kubat NJ, Cotton RJ, Boyden ES, Lin MZ, Tian L, Tolias AS, Poon JKS, Shepard KL, Roukes ML (2020)

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ (2020)

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tsuboi T, Kitaguchi T, Tian L, McHugh TJ, Hirase H (2020)

Nature Communications

Directed evolution of a selective and sensitive serotonin sensor via machine learning

Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L (2020)

Cell

Imaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators

Sabatini BL, Tian L (2020)

An expanded palette of dopamine sensors for multiplex imaging in vivo

Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L (2020)

Current Opinion in Chemical Biology

Imaging voltage and brain chemistry with genetically encoded sensors and modulators

Pal A, Tian L (2020)

Frontiers in Cellular Neuroscience

Biosensors show the pharmacokinetics of S-ketamine in the endoplasmic reticulum

Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA (2019)

Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V (2019)

eLife

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

Patriarchi T, Cho JR, Merten K, Marley A, Broussard GJ, Liang R, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L (2019)

Nature Protocols

Current Opinion in Biomedical Engineering

Measuring brain chemistry using genetically encoded fluorescent sensors

Andreoni A, Davis C, Tian L (2019)

A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system

de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S (2019)

Dissociable dopamine dynamics for learning and motivation

Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD (2019)

Nature Biomedical Engineering

Maps of neuronal activity across the mouse brain

Andreoni A, Tian L (2019)

Protein structures guide the design of a much-need tool for neuroscience

Scheerer P, Unger E, Tian L (2019)

Compendium of In-Vivo monitoring in Real-Time Molecular Neuroscience

Real-time monitoring of neuromodulators in behaving animals using genetically encoded indicators

Mizuno GO, Unger E, Tian L (2019)

Temporally and spatially distinct thirst satiation signals

Augustine V, Ebisu H, Zhao Y, Lee S, Ho B, Mizuno GO, Tian L, Oka Y (2019)

Biochemical Approaches for Glutamatergic Neurotransmission

Imaging glutamate with genetically encoded fluorescent sensors

Broussard G, Unger L, Liang R, Tian L (2018)

Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human down syndrome stem cell model

Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L (2018)

Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement

Corre J, van Zessen R, Loureiro M, Patriarchi T, Tian L, Pascoli V, Lüscher C (2018)

eLife

In vivo measurement of afferent activity with axon-specific calcium imaging

Broussard G, Liang R, Fridman M, Unger E, Meng GH, Xian X, Ji N, Petreanu L, Tian L (2018)

Nanodelivery of a functional membrane receptor to manipulate cellular phenotype

Patriarchi T, Shen A, He W, Baikoghli M, Cheng R., Xiang Y, Coleman M, Tian L (2018)

Scientific Reports

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L (2018)

Science

ACS Combinatorial Science

Combinatorial library screening with liposomes for discovery of membrane active peptides

Randy C, Yann T, Zsofia K, Amir S, Campos H, Alisha K, Liu R, Tian L, Lam K (2017)

Frontiers in Neuroinformatics

Automated functional analysis of astrocytes from chronic time-lapse calcium imaging data

Wang Y, Shi G, Miller DJ, Wang Y, Wang C, Broussard G, Wang Y, Tian L, Yu G (2017)

Nature: Microsystems & Nanoengineering 2

Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device

Gao Y, Broussard G, Haque A, Revzin A, Tian L (2016)

Advances in Neural Information Processing Systems

Graphical time warping for joint alignment of multiple curves

Zhi Y, Shi G, Miller DJ, Broussard G, Tian L, Yu G (2016)

Wnt regulates proliferation and neurogenic potential of Muller Glial cells through a Lin28/let-7 miRNA-dependent pathway in adult mammalian retina

Yao K, Qiu S, Tian L, Snider W, Flannery J, Scahffer D, Chen B (2016)

CDK1 enhances mitochondrial bioenergetics for radiation-induced DNA repair

Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ (2015)

ACS Chemical Neuroscience

Imaging chemical neurotransmission with genetically encoded fluorescent sensors

Liang R, Broussard G, Tian L (2015)

Frontiers in Molecular Neuroscience

Monitoring activity in neural circuits with genetically encoded indicators

Broussard G, Liang R, Tian L (2014)

An optimized fluorescent probe for visualizing glutamate neurotransmission

Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL (2013)

Frontiers in Molecular Neuroscience

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL (2013)

Two photon photophysics of fluorescent protein calcium indicators

Macklin J, Akerboom J, Schreiter ER, Tian L, Patel R, Iyer V, Karsh B, Colonell J, Harris TD (2013)

Biophysical Journal

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo

Zariwala HA, Borghuis BG, Hoogland TM, Madisen L, Tian L, De Zeeuw CI, Zeng H, Looger LL, Svoboda K, Chen TW (2012)

Activity in motor-sensory projections reveals distributed coding in somatosensation

Petreanu L, Gutnisky DA, Huber D, Xu NI, Connor DHO, Tian L, Looger LL, Svoboda K (2012)

Genetically Encoded Functional

Engineering and application of genetically encoded calcium indicators

Akerboom J, Tian L, Marvin J, Looger LL (2012)

Cold Spring Harbor Protocols

Imaging neuronal activity with genetically encoded calcium indicators

Tian L, Hires SA, Looger LL (2012)

Multiple dynamic representations in the motor cortex during sensorimotor learning

Huber DC, Gutnisky DA, Peron S, Connor DHO, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K (2012)

Optimization of a GCaMP calcium indicator for neural activity imaging

Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL (2012)

Proceedings of the National Academy of Sciences

Selective esterase-ester pair for targeting small molecules with cellular specificity

Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD (2012)

Progress in Brain Research

Neural activity imaging with genetically encoded calcium indicators

Tian L, Akerboom J, Schreiter ER, Looger LL (2012)

Imaging light responses of targeted neuron populations in the rodent retina

Borghuis BG, Tian L, Xu Y, Nikonov SS, Vardi N, Zemelman BV, Looger LL (2011)

Functional imaging of hippocampal place cells at cellular resolution during virtual navigation

Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW (2010)

Toward the second generation of optogenetic tools

Knopfel T, Lin MZ, Levskaya A, Tian L, Lin JY, Boyden ES (2010)

Journal of Biological Chemistry

Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design

Akerboom J, Rivera JDV, Guilbe MMR, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER (2009)

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL (2009)

Drug Discovery Today: Disease Models

Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems

Tian L, Looger LL (2008)

Reporting neural activity with genetically encoded calcium indicators

Hires SA, Tian L, Looger LL (2008)

Brain Cell Biology

Nature Structural & Molecular Biology

Where to start and when to stop

Tian L, Matouschek A (2006)

Nature Structural & Molecular Biology

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kB

Tian L, Holmgren RA, Matouschek A (2005)

Nature Structural & Molecular Biology

An unstructured initiation site is required for efficient proteasome-mediated degradation

Prakash S, Tian L, Ratliff KS, Lehotzky RE, Matouschek A (2004)

Olfactory identification and apolipoprotein E ε4 allele in mild cognitive impairment

Wang Q, Tian L, Huang Y, Song Q, He L, Zhou JN (2002)

Brain Research