Publications

All Publications

Opioidergic signaling contributes to food-mediated suppression of AgRP neurons

Sayar-Atasoy N, Yavuz Y, Laule C, Dong C, Kim H, Rysted J, Flippo K, Davis D, Aklan I, Yilmaz B, Tian L, Atasoy D (2024)

5-HT_FAsTR: A versatile, label-free, microplate assay to quantify serotonin transport and release using the genetically encoded fluorescent biosensor iSeroSnFR

Bukowski L, Strom M, Andersen J, Maesen J, Tian L, Sinning S (2023)

Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain

Chuapcoco MR, Flytzani NC, Goeden N, Octeau JC, Roxas KM, Chan KY, Scherrer J, Winchester J, Blackburn RJ, Campos, LJ, Man KNM, Sun J, Chen X, Lefevre A, Singh VP, Arokiaraj CM, Shay TF, Vendemiatti J, Jang MJ, Mich JK, Bishaw Y, Gore BB, Omstead V, Taskin N, Weed N, Levi BP, Ting JT, Miller CT, Deverman BE, Pickel J, Tian L, Fox AS, Gradinaru V (2023)

The residence of synaptically released dopamine on D2 autoreceptors

Condon AF, Robinson BG, Asad N, Dore TM, Tian L, Williams JT (2021)

Competition between stochastic neuropeptide signals calibrates the rate of satiation

Zhang SX, Kim A, Madara JC, Zhu PK, Christenson LF, Lutas A, Kalugin PN, Jin Y, Pal A, Tian L, Lowell BB, Andermann ML (2023)

Lighting up action potentials with fast and bright voltage sensors

Andreoni A, Tian L (2023)

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors

Vargas MV, Dunlap LE, Dong C, Carter SJ, Tombari RJ, Jami SA, Cameron LP, Patel SD, Hennessey JJ, Saeger HN, McCorvy JD, Gray JA, Tian L, Olson DE (2023)

Behavioral encoding across timescales by region-specific dopamine dynamics

Jørgensen SH, Ejdrup AL, Lycas MD, Posselt LP, Madsen KL, Tian L, Dreyer JK, Herborg F, Sørensen AT, Gether U (2023)

Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors

Dong C, Zheng Y, Long-Iyer K, Wright EC, Li Y, Tian L (2022)

Fluorescence screens for identifying central nervous system-acting drug-biosensor pairs for subcellular and supracellular pharmacokinetics

Beatty ZG, Muthusamy AK, Unger EK, Dougherty DA, Tian L, Looger LL, Shivange AV, Bera K, Lester HA, Nichols AL (2022)

Phasic locus coeruleus activity facilitates hippocampus-dependent trace fear memory formation

Wilmot JH, Puhger K, Roshgadol J, Tian L, Wiltgen BJ (2022)

Letting the little light of mind shine: Advances and future directions in neurochemical detection

Tjahjono N, Jin Y, Hsu A, Roukes M, Tian L (2022)

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

Klein Herenbrink C, Støier JF, Reith WD, Dagra A, Gregorek MAC, Cola RB, Patriarchi T, Li Y, Tian L, Gether U, Herborg F (2022)

Distinct sub-second dopamine signaling in dorsolateral striatum measured by a genetically-encoded fluorescent sensor

Salinas AG, Lee JO, Augustin SM, Zhang S, Patriarchi T, Tian L, Morales M, Mateo Y, Lovinger DM (2023)

Cell-type specific asynchronous modulation of PKA by dopamine during reward-based learning

Lee SJ, Lodder B, Chen Y, Patriarchi T, Tian L, Sabatini B (2021)

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J (2021)

Dopamine release in the nucleus accumbens core signals perceived saliency

Kutlu MG, Zachry JE, Melugin PR, Cajigas SA, Chevee MF, Kelly SJ, Kutlu B, Tian L, Siciliano CA, Calipari ES (2021)

Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition

Abraham AD, Casello SM, Schattauer SS, Wong BA, Mizuno GO, Mahe K, Tian L, Land BB, Chavkin C (2021)

A photoswitchable GPCR-based opsin for presynaptic inhibition

Copits BA, Gowrishankar R, O’Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, Shirley SE, Ma KKL, Vasquez AM, Stander MC, Kalyanaraman V, Vogt SK, Samineni VK, Patriarchi T, Tian L, Gautam N, Sunahara RK, Gereau RW, Bruchas MR (2021)

Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories

Melzer S, Newmark ER, Mizuno GO, Hyun M, Philson AC, Quiroli E, Righetti B, Gregory MR, Huang KW, Levasseur J, Tian L, Sabatini BL (2021)

Psychedelic-inspired drug discovery using an engineered biosensor

Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L (2021)

Integrated neurophotonics: Toward dense volumetric interrogation of brain circuit activity-at depth and in real time

Moreaux LC, Yatsenko D, Sacher WD, Choi J, Lee C, Kubat NJ, Cotton RJ, Boyden ES, Lin MZ, Tian L, Tolias AS, Poon JKS, Shepard KL, Roukes ML (2020)

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ (2020)

Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance

Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tsuboi T, Kitaguchi T, Tian L, McHugh TJ, Hirase H (2020)

Directed evolution of a selective and sensitive serotonin sensor via machine learning

Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L (2020)

Imaging neurotransmitter and neuromodulator dynamics in vivo with genetically encoded indicators

Sabatini BL, Tian L (2020)

An expanded palette of dopamine sensors for multiplex imaging in vivo

Patriarchi T, Mohebi A, Sun J, Marley A, Liang R, Dong C, Puhger K, Mizuno GO, Davis CM, Wiltgen B, von Zastrow M, Berke JD, Tian L (2020)

Imaging voltage and brain chemistry with genetically encoded sensors and modulators

Pal A, Tian L (2020)

Biosensors show the pharmacokinetics of S-ketamine in the endoplasmic reticulum

Bera K, Kamajaya A, Shivange AV, Muthusamy AK, Nichols AL, Borden PM, Grant S, Jeon J, Lin E, Bishara I, Chin TM, Cohen BN, Kim CH, Unger EK, Tian L, Marvin JS, Looger LL, Lester HA (2019)

Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1

Robinson JE, Coughlin GM, Hori AM, Cho JR, Mackey ED, Turan Z, Patriarchi T, Tian L, Gradinaru V (2019

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

Patriarchi T, Cho JR, Merten K, Marley A, Broussard GJ, Liang R, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L (2019)

Measuring brain chemistry using genetically encoded fluorescent sensors

Andreoni A, Davis C, Tian L (2019)

A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system

de Jong JW, Afjei SA, Pollak Dorocic I, Peck JR, Liu C, Kim CK, Tian L, Deisseroth K, Lammel S (2019)

Dissociable dopamine dynamics for learning and motivation

Mohebi A, Pettibone JR, Hamid AA, Wong JT, Vinson LT, Patriarchi T, Tian L, Kennedy RT, Berke JD (2019)

Maps of neuronal activity across the mouse brain

Andreoni A, Tian L (2019)

Protein structures guide the design of a much-need tool for neuroscience

Scheerer P, Unger E, Tian L (2019)

Real-time monitoring of neuromodulators in behaving animals using genetically encoded indicators

Mizuno GO, Unger E, Tian L (2019)

Temporally and spatially distinct thirst satiation signals

Augustine V, Ebisu H, Zhao Y, Lee S, Ho B, Mizuno GO, Tian L, Oka Y (2019)

Imaging glutamate with genetically encoded fluorescent sensors

Broussard G, Unger L, Liang R, Tian L (2018)

Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human down syndrome stem cell model

Mizuno GO, Wang Y, Shi G, Wang Y, Sun J, Papadopoulos S, Broussard GJ, Unger EK, Deng W, Weick J, Bhattacharyya A, Chen CY, Yu G, Looger LL, Tian L (2018)

Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement

Corre J, van Zessen R, Loureiro M, Patriarchi T, Tian L, Pascoli V, Lüscher C (2018)

In vivo measurement of afferent activity with axon-specific calcium imaging

Broussard G, Liang R, Fridman M, Unger E, Meng GH, Xian X, Ji N, Petreanu L, Tian L (2018)

Nanodelivery of a functional membrane receptor to manipulate cellular phenotype

Patriarchi T, Shen A, He W, Baikoghli M, Cheng R., Xiang Y, Coleman M, Tian L (2018)

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L (2018)

Combinatorial library screening with liposomes for discovery of membrane active peptides

Randy C, Yann T, Zsofia K, Amir S, Campos H, Alisha K, Liu R, Tian L, Lam K (2017)

Automated functional analysis of astrocytes from chronic time-lapse calcium imaging data

Wang Y, Shi G, Miller DJ, Wang Y, Wang C, Broussard G, Wang Y, Tian L, Yu G (2017)

Functional imaging of neuron-astrocyte interactions in a compartmentalized microfluidic device

Gao Y, Broussard G, Haque A, Revzin A, Tian L (2016)

Graphical time warping for joint alignment of multiple curves

Zhi Y, Shi G, Miller DJ, Broussard G, Tian L, Yu G (2016)

Wnt regulates proliferation and neurogenic potential of Muller Glial cells through a Lin28/let-7 miRNA-dependent pathway in adult mammalian retina

Yao K, Qiu S, Tian L, Snider W, Flannery J, Scahffer D, Chen B (2016)

CDK1 enhances mitochondrial bioenergetics for radiation-induced DNA repair

Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ (2015)

Imaging chemical neurotransmission with genetically encoded fluorescent sensors

Liang R, Broussard G, Tian L (2015)

Monitoring activity in neural circuits with genetically encoded indicators

Broussard G, Liang R, Tian L (2014)

An optimized fluorescent probe for visualizing glutamate neurotransmission

Marvin JS, Borghuis BG, Tian L, Cichon J, Harnett MT, Akerboom J, Gordus A, Renninger SL, Chen TW, Bargmann CI, Orger MB, Schreiter ER, Demb JB, Gan WB, Hires SA, Looger LL (2013)

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics

Akerboom J, Carreras Calderón N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen TW, Sarkisyan KS, Marvin JS, Bargmann CI, Kim DS, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER, Looger LL (2013)

Two photon photophysics of fluorescent protein calcium indicators

Macklin J, Akerboom J, Schreiter ER, Tian L, Patel R, Iyer V, Karsh B, Colonell J, Harris TD (2013)

A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo

Zariwala HA, Borghuis BG, Hoogland TM, Madisen L, Tian L, De Zeeuw CI, Zeng H, Looger LL, Svoboda K, Chen TW (2012)

Activity in motor-sensory projections reveals distributed coding in somatosensation

Petreanu L, Gutnisky DA, Huber D, Xu NI, Connor DHO, Tian L, Looger LL, Svoboda K (2012)

Engineering and application of genetically encoded calcium indicators

Akerboom J, Tian L, Marvin J, Looger LL (2012)

Imaging neuronal activity with genetically encoded calcium indicators

Tian L, Hires SA, Looger LL (2012)

Multiple dynamic representations in the motor cortex during sensorimotor learning

Huber DC, Gutnisky DA, Peron S, Connor DHO, Wiegert JS, Tian L, Oertner TG, Looger LL, Svoboda K (2012)

Optimization of a GCaMP calcium indicator for neural activity imaging

Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL (2012)

Selective esterase-ester pair for targeting small molecules with cellular specificity

Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD (2012)

Neural activity imaging with genetically encoded calcium indicators

Tian L, Akerboom J, Schreiter ER, Looger LL (2012)

Imaging light responses of targeted neuron populations in the rodent retina

Borghuis BG, Tian L, Xu Y, Nikonov SS, Vardi N, Zemelman BV, Looger LL (2011)

Functional imaging of hippocampal place cells at cellular resolution during virtual navigation

Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW (2010)

Toward the second generation of optogenetic tools

Knopfel T, Lin MZ, Levskaya A, Tian L, Lin JY, Boyden ES (2010)

Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design

Akerboom J, Rivera JDV, Guilbe MMR, Tian L, Hires SA, Marvin JS, Looger LL, Schreiter ER (2009)

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Tian L, Hires SA, Mao T, Huber D, Chiappe ME, Chalasani SH, Petreanu L, Akerboom J, McKinney SA, Schreiter ER, Bargmann CI, Jayaraman V, Svoboda K, Looger LL (2009)

Genetically encoded fluorescent sensors for studying healthy and diseased nervous systems

Tian L, Looger LL (2008)

Reporting neural activity with genetically encoded calcium indicators

Hires SA, Tian L, Looger LL (2008)

Where to start and when to stop

Tian L, Matouschek A (2006)

A conserved processing mechanism regulates the activity of transcription factors Cubitus interruptus and NF-kB

Tian L, Holmgren RA, Matouschek A (2005)

An unstructured initiation site is required for efficient proteasome-mediated degradation

Prakash S, Tian L, Ratliff KS, Lehotzky RE, Matouschek A (2004)

Olfactory identification and apolipoprotein E ε4 allele in mild cognitive impairment

Wang Q, Tian L, Huang Y, Song Q, He L, Zhou JN (2002)

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